Vol. 38 No. 2 Maret 2021
PERBEDAAN KADAR N-TERMINAL PRO BRAIN NATRIURETIC PEPTIDE PLASMA BERDASARKAN LUARAN FUNGSIONAL STROKE ISKEMIK AKUT
Gunawan Septa Dinata,* Syarif Indra*
THE DIFFRENCES IN PLASMA LEVEL N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE BASED ON ISCHEMIC STROKE FUNCTIONAL OUTCOME
ABSTRACT
Introduction: Brain natriuretic peptide (BNP) is neurohomone as cardiac natriuretic hormone, has an effect on systemic vascular system when ischemic stroke occur. BNP is secreted by myocardial and causes vasodilatation, natriuresis and diuresis. Increase myocardial wall pressure triggers pre-proBNP synthesis in myocardial. Pre-proBNP then was divided into an active form (BNP1-32) and inactive amino-terminal fragmen (NT-proBNP).
Objective: To evaluate the differences of plasma N-terminal pro brain natriuretic peptide (NT-proBNP) levels in acute stroke ischemic based on functional outcome of acute ishemic stroke patient.
Methods: This is an observational study that was conducted at neurology ward of M. Djamil Padang Hospital for acute stroke ischemic patients. The sample was selected by consecutive sampling method. Functional outcome was assessed by Modified Rankin Scale (mRS). Plasma NT-proBNP levels were analyzed by enzyme-linked immunosorbent assay (ELISA).
Results: The mean level of plasma NT-proBNP of acute ischemic stroke patient was 287.8±84.2 pg/mL. Data was analyzed using Kruskal Wallis and the result showed that there is a significant differences in plasma NT-proBNP (<72 hours) levels based on functional outcome of acute ischemic stroke, p value <0.05 (p=0.018).
Discussion: There is an differences in acute phase of NTproBNP plasma level with functional outcome ischaemic stroke.
Keywords: BNP, functional outcome, NT-proBNP
ABSTRAK
Pendahuluan: Brain natriuretic peptide (BNP) merupakan neurohormone sebagai cardiac natriuretic hormone, memiliki efek pada sistem vaskular sistemik saat terjadi stroke iskemik. BNP disekresikan langsung oleh miokardial yang menyebabkan vasodilatasi, natriuresis dan diuresis. Peningkatan tekanan dinding miokardial memicu sintesis dari pre-proBNP di miokardial. Kemudian, pre-proBNP menjadi bentuk aktif (BNP1-32) dan fragmen amino-terminal inaktif (NTproBNP).
Tujuan: Tujuan penelitian melihat perbedaan kadar N-terminal pro brain natriuretic peptide (NT-proBNP) plasma pada stroke iskemik akut berdasarkan luaran fungsional penderita stroke iskemik.
Metode: Penelitian ini adalah penelitian observasional, dilakukan di bangsal saraf Rumah Sakit M. Djamil Padang pada penderita stroke iskemik akut. Sampel dipilih dengan metode konsekutif. Kadar NT-proBNP plasma dianalisis dengan teknik enzyme-linked immunosorbent assay (ELISA). Luaran fungsional dinilai dengan Modified Rankin Scale (mRS).
Hasil : Didapatkan rerata kadar plasma NT-proBNP pada stroke iskemik fase akut adalah 287,8±84,2 pg/mL Analisis data dengan uji Kruskal Wallis menggambarkan terdapat perbedaan yang pasca kadar plasma NT-proBNP (<72 jam) berdasarkan luaran fungsional stroke iskemik dengan p<0,05 (p=0,018).
Diskusi: Terdapat perbedaan bermakna pada kadar NTproBNP plasma berdasarkan luaran fungsional stroke iskemik akut.
Kata kunci: BNP, luaran fungsional, NT-proBNP
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*Bagian Neurologi FK Universitas Andalas/RSUP Dr.M.Djamil Padang.
Korespondensi: indrasyarifneuro@gmail.com.
